Diabetes. 2005;54(6):1615-1625. The polyol pathway, shown schematically in Fig. 2, focuses on the enzyme aldose reductase. Aldose reductase normally has the function of reducing toxic aldehydes in ...

Aldose Reductase (ALR2): An enzyme that catalyzes the conversion of glucose to sorbitol, playing a key role in the polyol pathway associated with diabetic complications. Polyol Pathway ...