To maintain ploidy, unidirectional progression through the phases of the cell cycle (G1 → S → G2 → M → ... yeast cells arrest in either pre- or post-Start phase (lever up or down ...

leading to cell cycle arrest in the G1 phase. Further investigation into the role of CDK4/CDK6 in ESCC was conducted through CRISPR-mediated gene knockout experiments. The depletion of CDK4/CDK6 ...