Chromosomal translocation fusion proteins contain a unique sequence at the junction of the fusion entities. The development of immunotherapies contingent on lymphocyte recognition of the junction ...

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase first identified in a chromosomal translocation associated with some anaplastic large cell lymphomas (ALCL), a subset of T-cell non ...

This method is most useful for examining chromosomal translocations, especially ones involving the Y chromosome. Taken together, these banding techniques offer clinical cytogeneticists an arsenal ...

Medically reviewed by Marla Anderson, MD Multiple myeloma is a rare type of blood cancer that starts in your plasma cells.

In the case of oncogenic gene fusions, the hybrid mRNA is unique to the tumor cell. Attempts have been made to circumvent the problems of antisense oligonucleotides by developing highly target ...

Professor Terry Rabbitts’ research is focussed on new strategies using intracellular antibodies and derivates for therapy aimed at hard-to-drug chromosomal translocation gene products. Our research is ...

Lucy Glade-Wright and Jonno Rodd say they have IVF to thank not only for their son Otis and his baby brother who will be born ...