Chromosomes carrying the mutation causing the fragile X [ fra (X) ] syndrome have been shown to have an unstable DNA sequence close to or within the fragile site. The length variation is located ...

Fragile X syndrome is caused by an expansion of CGG nucleotide repeats in the FMR1 gene at the end of the long arms of the X chromosome. To identify the mutation, researchers culture cells in media ...

MIT neuroscientists have made a breakthrough in treating fragile X syndrome by leveraging a novel neurotransmitter signaling ...

“The mutation that causes FXS can ... “Because females have two X chromosomes, and usually only one of them is affected by Fragile X, the impact of the condition varies,” explains Richardson.

Females (XX) carry twice as many X-linked genes on their sex chromosomes as males (XY). How do cells control gene expression to manage this potentially lethal dosage problem? A prime example of X ...

Building on more than two decades of research, a study by MIT neuroscientists at The Picower Institute for Learning and Memory reports a new way to treat pathology and symptoms of fragile X syndrome, ...

UCSF researchers found that brain cells age more quickly when they rely solely on the X chromosome inherited from a female's ...

For example, mutations in the FMR1 gene on the X chromosome cause fragile X syndrome, a condition associated with intellectual disability. Turner syndrome, a condition where females are born with only ...

Human biological sex is determined by the sex chromosomes X and Y. In most cases ... generation which helps to eliminate damaging gene mutations," Darren Kent, a professor at the University ...

Previous research has hinted that the X chromosome is vital to brain health. Mutations in the X chromosome may cause intellectual disability, and women born with just one X chromosome (a diagnosis ...