Estrogen functions through binding of two different estrogen receptors (ESRs), ESR1 and ESR2 ... in osteoblasts (cells that make bone), osteoclasts (cells that absorb bone), osteocytes (a final ...

Opens in a new tab or window So, the subgroup analysis here is looking at variant allele frequency of ESR1 mutations and PIK3CA mutations. And the reason is we know that when we get liquid biopsy ...