Southwest United Graduate School, Yunnan Key Laboratory of Cell Metabolism and Diseases, State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan Center for Life Sciences, ...
“The first generation of peptide drugs, such as insulin, were either natural hormones or close derivatives. The second generation came from phage and mRNA display where large libraries of ...
In the latest project, they focused on an insulin region, specifically a peptide, or a chain of amino acids—known as the B chain of insulin, or B:9-23—that is targeted by the immune cells in type 1 ...
stimulated insulin. The basal plasma glucagon levels were chosen to simulate portal glucagon levels. Results—Peptide infusions produced the desired hormone levels. The amount of glucose required ...