In the case of the enzyme, isocitrate dehydrogenase, the kinetic alterations ... the aspartate receptor becomes an inhibitor of the kinase cascade. The aspartate receptor is also induced into ...

Rigel Pharmaceuticals has enrolled the first subject in a Phase I trial of its oral spleen tyrosine kinase (SYK ... for individuals with mutated isocitrate dehydrogenase-1 (mIDH1) acute myeloid ...