However, mechanistic studies to support the conclusion that mitochondrial function is increased in the tumours remain incomplete and would benefit from experiments that would directly interrogate ...

Acute pancreatitis (AP) is a gastrointestinal disorder characterized by inflammation and necrosis of the pancreatic acinar cells. Mitochondrial homeostasis is key to energy metabolism and redox ...

But in the mammalian brain, aging comes with mitochondrial metabolism deterioration, which affects the neuronal and circuit functionality. The disruption of the OXPHOS pathway results in oxidative ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

Mitochondrial behaviour under low oxygen stress is important in programmed cell death signalling under low oxygen conditions. This is being studied in the wheat seedlings (roots) and protoplasts and ...

I discovered a conserved function for the mitochondrial protein unfoldase ClpX as an activator of the initial enzyme in heme biosynthesis, ALA synthase. ClpX performs an unusually targeted, partial ...