To investigate whether the Cdc2-like kinase 2 (CLK2) is expressed in hypothalamic ... 12 h-fasted mice were injected (i.p.) with sodium pyruvate (2 g kg −1) and blood samples were ...

By combining STI571 with leptomycin B (LMB) to block nuclear export, we trapped BCR–ABL in the nucleus and the nuclear BCR–ABL tyrosine kinase activates apoptosis. As a result, the combined ...

Mutations occur to this DNA in the same way as DNA found in the nucleus, but studying ... The researchers found that by blocking the kinase "off switch" of pyruvate dehydrogenase, they could ...