The product of this tumor suppressor gene, a 105-kilodalton polypeptide called pRB, `is a cell cycle regulator. The pRB polypeptide inhibits cell proliferation by arresting cells at the G1 phase of ...

Cells were lysed with 1% SDS in 10 mM Tris, pH 7.5, and protein extracts (pRb, 10 μg; p16, 20 μg) were separated by SDS-PAGE and transferred to a nitrocellulose membrane. We stained the blots ...

Many signal transduction proteins can be compared to cellular samurai. Like samurai warriors of old, they show absolute obedience to their masters. When their existence interferes with the proper ...