Diabetes. 2005;54(6):1615-1625. The polyol pathway, shown schematically in Fig. 2, focuses on the enzyme aldose reductase. Aldose reductase normally has the function of reducing toxic aldehydes in ...

Finally, decreased GAPDH activity activates the polyol pathway, increases intracellular ... the San Antonio Heart Study studied men without diabetes or impaired glucose tolerance.

escalation of the polyol and other collateral glycolysis pathways, 4) impaired hexokinase (HK) activity and glucose utilization in the glycolytic pathway, and 5) further escalation of the polyol ...