In cancers, all translocations involving ALK produce fusion proteins with constitutive tyrosine kinase activity that in most cases derives from spontaneous dimerization induced by the different ...

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high ...

More than 60 tyrosine kinases have already been successfully ... validate the trend toward screening new protein kinase inhibitors of various kinases for use in different therapeutic areas.

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high morbidity and mortality worldwide. In affected people, insulin is unable to ...

Researchers at the Harvard Medical School discovered that the enzyme GUK1 promotes lung cancer growth by boosting the ...

The introduction of anti-VEGF agents has revolutionized the field of medical retina care by reducing rates of vision loss and ...