Ras, in turn, initiates a phosphorylation cascade ... Integrins, which are single transmembrane spanning receptors, lack intrinsic tyrosine kinase activity. Instead, they serve as scaffolds ...

MAP kinase, Raf-1, and RSK," Cell, 68:1041-50, 1992. Kenneth W. Wood (Dana-Farber Cancer Institute, Boston): "RAS plays a central role in receptor tyrosine kinase (RTK)-stimulated signaling pathways, ...

S.M. Thomas, M. DeMarco, G. D'Arcangelo, S. Halegoua, J.S. Brugge, "Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of ...

Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular ... Sorafenib is an oral tyrosine kinase inhibitor able to inhibit VEGF receptors 1, 2 and 3, PDGF receptors α and β, RET ...

Hsp90 is a chaperone required for maintaining the proper conformation of several important signaling proteins, including transmembrane tyrosine kinases ... for oncogenic RAF kinase-driven ERK ...

The LEAP-017 trial evaluated lenvatinib, a tyrosine kinase inhibitor (TKI) with preferential activity in RAS-mutant mCRC patients, who make up the majority of Phase 3 third-line or higher (3L ...