Signal transducer and activator of transcription 6 (STAT6) is a member of the STAT family involved in the regulation of immune response and inflammation. The development of SH2 domain inhibitors ...

However there has been no indication from Cbl's sequence that it contained an SH2 domain — the archetypal phospho-tyrosine binding motif. Consequently the recent structure of Cbl from Michael ...

These phosphotyrosine interaction domains have three distinct biological roles: (i) recruiting SH2 or PTB domain-containing proteins to tyrosine-phosphorylated and activated receptor tyrosine ...