Ribosomes are the sites in a cell in which protein synthesis takes place. Cells have many ribosomes, and the exact number depends on how active a particular cell is in synthesizing proteins.

Ribosomes were first visualized in electron micrographs in 1943 (ref. 54) and the basic steps of translation were defined in the 1960's. The next four decades witnessed tremendous advances in our ...

In this valuable study, Roiuk et al employed a combination of ribosome profiling and reporter assays to provide convincing evidence that eIF2A is not involved in translational regulation in cultured ...

Ribosomal translation is the process by which cells synthesize proteins based on the genetic instructions encoded in messenger RNA. It is essential for life, yet it is an incredibly complex process ...

recognizes and destroys incomplete proteins that protrude from large ribosomal subunits that become detached from the rest of the ribosome when protein translation stalls. “We wanted to understand how ...

Researchers mapped HIV-1’s translation strategy, revealing RNA elements like uORFs, iORFs and an intricate frameshift site ...

Girolline, a compound extracted from the sea sponge Pseudaxinyssa cantharella, has been investigated for possible antitumor ...

The catalytic center of the ribosome, known as the peptidyl transferase center (PTC), is composed entirely of rRNA. The PTC is highly conserved across all domains of life, highlighting the fundamental ...

During protein synthesis, the genetic information stored in DNA is first transcribed into mRNA. The mRNA then travels to the ribosome, where translation occurs. Here's how anticodons facilitate the ...

We call this a complementary copy. The newly formed strand of mRNA is now ready to leave the nucleus and travel to the ribosome. After translation, the polypeptide is finally folded into the ...

playing a key role in two translation stages: initiation and elongation (helping ribosomes move along the mRNA and add amino acids to the protein chain). Specifically, eIF-5A helps when the ...