The underlying cause of AS is the lack of expression of the UBE3A gene, which is imprinted in neurons, meaning that only the maternal allele is active while the paternal allele is silenced.

in the UBE3A gene inherited from the mother. The condition can also be caused by inheritance of two normal copies of UBE3A from the father, with no copy inherited from the mother. Other AS ...

Angelman syndrome is caused by several genetic mutations, but the most significant is loss of function in the maternally inherited form of the UBE3A gene, which leads to complications in the ...

This is one of 22 cutting-edge projects selected to share in a total of $8.1 million in grants raised through the Eagles ...

(MENAFN- PR Newswire) The team at UCLA is further developing this gene therapy approach in which a patient's own blood stem cells can be modified to add a healthy copy of the UBE3A gene that is ...