Oligo 1(top strand for sense):5＇-GGATCCTAATACGACTCACTAATA-G 1 N 2-18 C 19-3 ... N 2-18 G 19 (sense)-AAGTTCTCT(loop)-C 19 N 18-2 G 1 (antisense)-AA-5＇ 图3.产生siRNA 或发夹siRNA的模板所需要的DNA寡聚核苷酸。靶mRNA的正义序列 ...

With many such obstacles overcome, along with a handful of regulatory approvals granted, ASO- and siRNA-based therapies ... complements and binds to a sense strand of DNA or the mRNA directly.

Evidence has also shown that siRNA is involved in antiviral defense in certain plant and animal species. Plants are able to fight viral infection by using the viral ssRNA to generate dsRNA ...