This content introduces the physiological and pathological importance of protein kinases, kinase inhibitors approved for ...

Shenzhen Zhongge Biotechnology Co. Ltd. has divulged AMP-activated protein kinase α1β1γ1 activators reported to be useful for the treatment of acute kidney injury, alopecia, chronic kidney disease, ...

Tyrosine phosphorylation of the EGFR leads to the recruitment of other signaling proteins including phospholipase Cγ and the non-receptor tyrosine kinase c-Src. EGFR activation also leads to ...

The intestinal epithelium is a highly dynamic barrier that regulates digestion, absorption, immune responses, and communication between the gut microbiota and the nervous system.

Melbourne-based scientists have, for the first time, discovered how to "switch off" a molecule which is one of the top ...

Medically reviewed by Richard N. Fogoros, MD Your body produces the enzyme creatine kinase (CK) or creatine phosphokinase to ...

Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.

Cystic fibrosis is a life-threatening disease predominantly with respiratory symptoms. Most of the subjects with the disease harbor the F508del variant in the CFTR gene that causes the protein to ...