Aldose Reductase (ALR2): An enzyme that catalyzes the conversion of glucose to sorbitol, playing a key role in the polyol pathway associated with diabetic complications. Polyol Pathway ...

Diabetes. 2005;54(6):1615-1625. The polyol pathway, shown schematically in Fig. 2, focuses on the enzyme aldose reductase. Aldose reductase normally has the function of reducing toxic aldehydes in ...

Treatment with AT-001, a highly selective aldose reductase inhibitor, had no significant effect on exercise capacity as measured by peak oxygen uptake (VO2) among individuals with diabetic ...

Oral protein kinase Cβ2/1 inhibitor, ruboxistaurin. - More effective aldose reductase inhibitors. Benfothiamine. Inhibitors of leukostasis, such as anti-inflammatory agents. Use of hyaluronidase ...

through an aldose/ketose isomerase YihS. The SF is phosphorylated to 6-deoxy6-sulfofructosephosphate (SFP) by an ATP-dependent SF kinase YihV. The SFP is then cleaved into 3-sulfolactaldehyde (SLA) ...

Korah leads a rebellion against Moses and Aaron; plague sent by God; Aaron’s rod; duties for priests; the tithe offering Korah, Dathan, and Abiram rose up before Moses, with certain of the children of ...

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We have explained various metabolic abnormalities caused by hyperlipidemia, hyperglycemia, polyol signaling pathway, AGEs formation, PKC pathway, and hemosome pathway for enhanced generation of ROS, ...

Working with a diverse panel of rice accessions grown in field conditions, this valuable study measures changes in transcript abundance, tests for patterns of selection on gene expression, and maps ...

Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany Center for Synthetic Microbiology (SYNMIKRO), 35043 Marburg, Germany ...