The cyclic AMP/protein kinase A (cAMP/PKA) pathway is one of the most common and versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target PKA to specific substrates ...

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, Colorado 80045, ...

Here we report an activity-dependent stabilization of the MAP kinase (MAPK) pathway, prominent in hippocampal dendrites. The longevity of the signal in these dendrites was increased to hours when ...

AMP or ADP (adenosine-5'-diphosphate) then binds the γ subunit of AMPK and activates the kinase by 3 main mechanisms: allosteric activation of the α catalytic subunit, enhanced phosphorylation of the ...

Study shows that cannabidiol (CBD) enhances endurance exercise in mice by reshaping gut microbiota, boosting mitochondrial ...

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One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in many aspects of immune mediated inflammatory responses ...

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase ... in cancers results in the activation of several downstream pathways that are shared with other tyrosine kinases.

Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that is present in all eukaryotic cells and plays key roles in various extracellular, cytosolic, and nuclear signaling pathways. Two ...

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Amp (AMP) is a decentralized collateral token facilitating fast and secure payment transactions on the Flexa network. The goal of Amp is to make cryptocurrencies better equipped to be used as everyday ...