In this Review, familial and sporadic neurological disorders reported to have an etiological link with DNA repair defects are ... and four (ataxia-telangiectasia, ataxia-telangiectasia-like ...

A number of these disorders have a definitive link to an inherited or acquired defect in one of the DNA repair pathways. Table 1 lists these disorders along with the known genetic DNA repair ...

enhanced DNA repair, and altered cell cycle checkpoints and cell communication signals provided by the microenvironment. The fact that DNA double-strand breaks are highly cytotoxic is exploited by DNA ...

DNA damage response inhibitors are widely used anti-cancer agents that have potent activity against tumor cells with deficiencies in various DNA damage response proteins such as BRCA1/2. Inhibition of ...

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This material on this page is ©2025 American Society of Clinical Oncology, all rights reserved. Licensing available upon request. For more information, please ...

announced the online publication of safety data from patients with Ataxia-Telangiectasia (A-T) treated with EryDex for a minimum of 24 months in Frontiers in Neurology. "A-T is a rare pediatric ...

QUICK FIX: From left, Frederick Alt and Guillermo Taccioli and their colleagues identified DNA-dependent kinase as a key enzyme involved in DNA repair. The way that DNA repairs itself recently has ...

Maha Hussain joins Alicia Morgans sharing an overview of the PROfound study design. The trial was intended to look at the second line setting and the intent was to capture patients who may be less ...