Moreover, the IFN score has the potential to function as a marker in monitoring treatment responses and for ... These data reveal similar activation of IFN-regulated genes in simultaneously sampled ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

However, there is strong agreement that α-SMA is not an exclusive marker for activated PSC. It is also expressed by myofibroblasts, smooth muscle cells and pericytes in blood vessels as well as the ...

High serum CXCL13 levels are predictive of treatment failure with first-line MTX among patients with early RA.

Our genes contain all the instructions our body needs to function, but their expression must be finely regulated to guarantee ...

T-cell therapy, originally developed for haematological malignancies, has recently emerged as a promising therapy for ...

Jan. 15, 2025 — While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows.

In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.

Epidermal growth factor receptor (EGFR) is a major driver of cancer dissemination and target for anti-cancer therapies but ...

Researchers have discovered that DNA and RNA epigenetics form a complementary system that precisely regulates gene activity, ...