Bruton’s tyrosine kinase (Btk) deficiency preferentially eliminates autoreactive B cells while sparing normal humoral responses, but has not been studied in mucosal immunity. Commensal microbes and ...

2021), (Wang et al., 2022b). Therefore, the exploration of novel targets in gastric cancer is desperately in need. Bruton’s tyrosine kinase (BTK) is known to regulate multiple anti-apoptotic pathways, ...

Here, we build on recent findings implicating gain-of-function mutations in the BCL10 signaling protein as drivers of resistance to Bruton’s tyrosine kinase (BTK) inhibitors. We show mutant ...

Michelle Bruton has been covering action sports for more than a decade, including X Games, Summer and Winter Olympics and Paralympics, Dew Tour, world championships, and more. She is originally ...

Panelists discuss how data from Mansour and colleagues suggesting potential Bruton tyrosine kinase (BTK) inhibitor discontinuation after 2+ years of therapy opens up new treatment strategy ...

A new study has challenged conventional wisdom on oxygen reduction reaction (ORR) catalysts by uncovering a novel reaction pathway in weak-binding metal–nitrogen–carbon (M–N–C) single-atom ...

Orelabrutinib is a Bruton tyrosine kinase inhibitor that has received marketing ... The information on this site has been included in good faith for general informational purposes only.

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase first identified in a chromosomal translocation associated with some anaplastic large cell lymphomas (ALCL), a subset of T-cell non ...

This evening will see cloud cover break in places to give some clearer spells. Cloud thickening into the night with some patchy blustery spells of rain developing, heavy in spots. Winds ...

The mechanistic target of rapamycin (mTOR) is a serine/threonine kinase whose activity contributes to leukemia proliferation and survival. Compounds targeting the mTOR active site inhibit ...