Dec. 10, 2024 — In a single IV injection, a gene therapy targeting cBIN1 can reverse the effects of heart failure and restore heart function in a large animal model. The therapy increases the ...

Gene regulation refers to the mechanisms that act to induce or repress the expression of a gene. These include structural and chemical changes to the genetic material, binding of proteins to ...

Gene expression is the generation of a functional gene product from the information encoded by a gene, through the processes of transcription and translation. Gene products are often proteins ...

The company raised $200 million after early findings hinted its therapy could be more potent than others like it, including Sarepta Therapeutics’ Elevidys.

While hsa-miR-32-5p exclusively regulated ECM-related genes (COL1A2 and ITGA5), NR1H2 and SNAI1 also targeted other pathways (adhesion ... The MiRGTF-net tool allows one to construct miRNA–gene–TF ...

A research team has identified the core gene expression networks regulated by key proteins that fundamentally drive phenomena such as cancer development, metastasis, tissue differentiation from ...

Transcription factors are important regulators of gene expression. The effects of human amniotic MSCs (hAMSCs ... treated group and downregulating the expression of the pro-fibrogenic genes TGF-β1, ...

Chromosome 7 COL1A2 (collagen, type 2, alpha 2) Same Chromosome 9 COL5A1 (collagen, type 5 alpha 1) Same Chromosome 2 COL5A2 (collagen, type 5, alpha 2) Same ...

It is important to identify infants of affected women as high-risk infants. Scrutinize the maternal history and, when possible, determine the specific EDS type of the mother or affected family ...

Objective Tumour heterogeneity represents a major obstacle to accurate diagnosis and treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas to delineate molecular ...

COL1A2-related, dog (MONDO:1012791) porcine stress syndrome, DMD-related, pig (MONDO:1012729) neuronal ceroid lipofuscinosis, ATP13A2-related, dog (MONDO:1012707) genetic epilepsy with febrile ...

Enhancing a low-cost, minimally invasive screening test for dihydropyrimidine dehydrogenase mutations linked to 5-fluorouracil sensitivity by integrating computational mutation predictions. This is an ...