The markers analysed were: erythrocyte sedimentation rate (ESR); HLA-DRB alleles typed by restriction fragment length polymorphism; and C reactive protein, cartilage oligomeric matrix protein (COMP), ...

found that lubricin prevented wear and reduced friction by surface grafting lubricin-infused hyaluronic acid and hyaluronic acid. Raj et al. (2017) anchored cartilage oligomeric matrix protein (COMP) ...

Keter D, et al. Synovial fluid dual-biomarker algorithm accurately differentiates osteoarthritis from inflammatory arthritis. J Orthop Res. 2025;43(2):304-310. doi:10.1002/jor.26005 ...

The hospital’s research focuses on the use of biomarkers, specifically the serum cartilage oligomeric matrix protein (COMP), to detect osteoarthritis in its nascent stages. By measuring the ...

Background: Idiopathic pulmonary fibrosis (IPF) is a life-threatening disease whose etiology remains unknown. This study aims to explore diagnostic biomarkers and pathways involved in IPF using ...

Figure 1. Full activation of MGP (matrix Gla protein) requires 2 posttranslational modifications, that is, vitamin K–dependent carboxylation of glutamate at positions 2, 37, 41, 48, and 52 and serine ...

OBJECTIVES Matrix metalloproteinases (MMPs) are thought to be major mediators of cartilage destruction. Osteoarthritis (OA) is characterised by cartilage degradation. This study explores gene ...

Advances in spatial ‘-omics’, such as transcriptomics and proteomics, have provided vital insights into cartilage microenvironments, revealing cellular diversity, zonal organization and links ...

Department of Cardiovascular Sciences, University of Leicester, University Road, Leicester, Leicester LE1 7RH, U.K. Department of Cardiovascular Sciences, University ...

Getting enough protein daily is essential for your overall health. Healthy protein sources include eggs, nuts, lean meats, fish, dairy, and certain grains. Proteins are a large category of ...

To better distinguish between these possibilities, we identified 220 gene–trait pairs in which protein-coding variants influence a complex trait or its Mendelian cognate. Despite the presence of ...