Chromosomes carrying the mutation causing the fragile X [ fra (X) ] syndrome have been shown to have an unstable DNA sequence close to or within the fragile site. The length variation is located ...

Building on more than two decades of research, a study by MIT neuroscientists at The Picower Institute for Learning and ...

Fragile X syndrome is caused by an expansion of CGG nucleotide repeats in the FMR1 gene at the end of the long arms of the X chromosome. To identify the mutation, researchers culture cells in media ...

“The mutation that causes FXS can ... “Because females have two X chromosomes, and usually only one of them is affected by Fragile X, the impact of the condition varies,” explains Richardson.

MIT neuroscientists have made a breakthrough in treating fragile X syndrome by leveraging a novel neurotransmitter signaling ...

Females (XX) carry twice as many X-linked genes on their sex chromosomes as males (XY). How do cells control gene expression to manage this potentially lethal dosage problem? A prime example of X ...

For example, mutations in the FMR1 gene on the X chromosome cause fragile X syndrome, a condition associated with intellectual disability. Turner syndrome, a condition where females are born with only ...

Some mutations can affect the structure of one or more chromosomes - these are chromosome structure mutations.