Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle or transcription, whose activity requires association with specific cyclin subunits.

Our study demonstrates that cyclin-dependent kinase 5 (Cdk5) activity is modulated by light and regulates phase shifts of the circadian clock. We observed that knocking down Cdk5 in the SCN of mice ...

Greatwall, a conserved MAST-like kinase with crucial mitotic entry functions, is curiously absent in worms. Here, the single ...

Cyclin-dependent kinases (Cdks) play an essential role in this coordination ... The choice of these dilutions was based on the protein concentration assay and the information retrieved in literature.

A "pocket" on the protein cyclin B is responsible for ensuring ... The reason for this lies in the cyclins' cooperation with a kinase. Kinases are responsible for phosphorylating amino acids ...

The dysregulation of protein kinase activity plays a pivotal role in the pathogenesis of several diseases, including cancer. Therefore, protein kinases have become some of the most important drug ...

When a cancer cell no longer makes a particular functioning protein, it can become dependent ... which are inhibitors of the cyclin-dependent kinase enzymes CDKN4 and CDKN6. This leads to ...

IDR-RBPs are particularly relevant in the nervous system and their dysfunction is associated with neurodegenerative diseases and brain tumor development. Serpine1 mRNA-binding protein 1 (SERBP1) is a ...

Getting enough protein daily is essential for your overall health. Healthy protein sources include eggs, nuts, lean meats, fish, dairy, and certain grains. Proteins are a large category of ...

Best whey-protein powders Best collagen-protein powder Best plant-based protein powders All the other protein powders I’ve tried Protein powders can be found in thousands of formulations on tens ...

Figure 1. Full activation of MGP (matrix Gla protein) requires 2 posttranslational modifications, that is, vitamin K–dependent carboxylation of glutamate at positions 2, 37, 41, 48, and 52 and serine ...