DNA damage response inhibitors are widely used anti-cancer agents that have potent activity against tumor cells with deficiencies in various DNA damage response proteins such as BRCA1/2. Inhibition of ...

This extension builds on a 2024 agreement to define and discover biomarkers within the DNA damage response (DDR) biological space to predict the clinical benefit of one or more drugs in Debiopharm ...

This extension builds on a 2024 agreement to define and discover biomarkers within the DNA damage response (DDR) biological space to predict the clinical benefit of one or more drugs in Debiopharm’s ...

These findings emphasize the importance of DNA repair pathways in DAC response and provide potential biomarkers. A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives ...

Our understanding of the DNA damage responses of human cells to radiation has increased remarkably ... IR is prevalent in various aspects of daily life, causing cellular damage through multiple ...

The RNA-based response appears to be faster and more effective at protecting skin from further damage than previously understood DNA damage pathways. “Understanding how our skin responds at the ...

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