The Clean Development Mechanism (CDM), defined in Article 12 of the Protocol, allows a country with an emission-reduction or emission-limitation commitment under the Kyoto Protocol (Annex B Party) to ...

While performing a high-throughput screen (HTS) that identified the hits that led to the discovery of TNG908 and TNG462, we embarked on a structure-based design effort to switch the mechanism of ...

Enzyme mechanisms are the chemical transformations, and the steps within them, generated by enzymatic action on substrates. The mechanism of enzyme catalysis is similar in principle to other types ...

Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin ...

Lissencephaly is a severe neurodevelopmental disease often caused by mutations in the Dcx gene. Using a human cellular model of lissencephaly, the authors report that DCX restricts neuronal ...

The most commonly mutated ALS-linked genes are reviewed with an emphasis on disease-causing mechanisms. The cellular processes involved in ALS pathogenesis are discussed, with evidence implicating ...

Growing demand for tryptamine APIs stems from their anti-cancer potential, pharmaceutical uses, and role as a neurotransmitter modulator i ...

This article will review the mechanisms of activation of alternative, classical, and lectin pathways, the formation of C3 and C5 convertases, the action of anaphylatoxins, and the ...

In this Review, we summarise common mechanisms driving acute and long-term side-effects and discuss monitoring strategies for radiotherapy survivors. We explore ways to mitigate toxic effects through ...

Cold-pressed hazelnut meal cake (Liaoning, China), AAPH (2,2'-azobis(2-methylpropionamidine)dihydrochloride) was purchased from APExBIO (Houston, USA), 5,5'-dithiobis(2-nitrobenzoic acid)(DTNB) and ...

Structures of some of the most important benzodiazepine derivatives commercially available. All reagents and solvents were used as purchased from Sigma-Aldrich (São Paulo, Brazil) without further ...