While performing a high-throughput screen (HTS) that identified the hits that led to the discovery of TNG908 and TNG462, we embarked on a structure-based design effort to switch the mechanism of ...

Growing demand for tryptamine APIs stems from their anti-cancer potential, pharmaceutical uses, and role as a neurotransmitter modulator i ...

Department of Chemistry University of Tennessee, Knoxville, Tennessee 37996-1600, United States ...

Can include rhythm, melody, harmony, dynamics, texture, timbre and structure. of the music such as their melody close melodyDifferent pitched notes played one after another making a tune., ...

Many drugs are being administered to tackle coronavirus disease 2019 (COVID-19) pandemic situations without establishing clinical effectiveness or tailoring safety. A repurposing strategy might be ...

Summary: Entrepreneurs often grapple with the decision of whether to structure their business as a Company or a Limited Liability Partnership (LLP). Both offer the advantage of limited liability and ...

The amide I band (1700−1~1600 cm−1) is the most commonly used band to reflect changes in protein secondary structure. The secondary structure of hazelnut protein is shown in Table 1, including those ...

Structures of some of the most important benzodiazepine derivatives commercially available. All reagents and solvents were used as purchased from Sigma-Aldrich (São Paulo, Brazil) without further ...