Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver ...

The swelling was bilaterally symmetrical ... bile-duct proliferation, hepatic-cell necrosis and the presence of hyaline degeneration ("alcoholic hyaline") 9 were found. Six patients survived ...

Scientists have discovered a new type of cell in the liver that plays a critical role ... excessive bleeding, brain swelling and multi-organ dysfunction. Depending on the cause, some cases of ...

HHMI researchers solve a longstanding mystery about the origin of new cells in the liver. Howard Hughes Medical Institute (HHMI) scientists have identified stem cells in the liver that give rise to ...

This suggests these cells may be useful as new therapeutic targets for various liver conditions. The work appears in the journal Immunity. The specific functions of these cells in the context of ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...