The anaplastic lymphoma kinase (ALK) is the oncogene of most anaplastic large cell lymphomas (ALCL), driving transformation through many molecular mechanisms. In this Review, we will analyse how ...

Plants live under various biotic and abiotic stress conditions, and to cope with the adversity and severity of these conditions, they have developed well-established resistance mechanisms. These ...

A catalytic mechanism is the sequence of elementary reactions by which a catalytic reaction proceeds. The behaviour of nanoconfined water can be very different from that of the bulk and is ...

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, Colorado 80045, ...

The PI3K signaling pathway is commonly dysregulated in HR-positive breast cancer, often due to activating PIK3CA mutations, which have been identified as a potential mechanism of intrinsic ...

On the other hand, mechanisms of acquired resistance to 'pathway-targeted' drugs, such as the various clinically active kinase inhibitors, have been somewhat more straightforward to elucidate and ...

School of Electrical and Computer Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel ...