据辉瑞官网介绍，PF-07934040是一种泛KRAS“ON/OFF”抑制剂，具有抗野生型 (wt)KRAS和主要突变亚型的活性，对NRAS或HRAS无活性。PF-07934040显示与KRAS wt的OFF (GDP-bound)和ON ...

站在产业视角，这笔交易折射出全球抗癌药物研发的新趋势。据EvaluatePharma预测，到2030年RAS抑制剂市场规模将突破200亿美元，其中KRAS靶点占比超七成。中国创新药企通过差异化布局，正在改写全球竞争格局：在KRAS-G12C领域，安进、Mirati等国际药企已建立先发优势，而针对KRAS非经典突变及泛RAS抑制的赛道仍存巨大空白。JYP0015的临床推进，标志着我国在新一代肿瘤靶向 ...

因为这些信号会导致细胞生长和分裂，过度活跃的 Ras 信号最终会导致癌症。 人类的三种 Ras 基因HRAS、KRAS和NRAS，分别定位在11、12和1号染色体上，都参与细胞内的信号传递。永久性激活 RAS 的突变存在于 20% 至 25% 的人类肿瘤中。KRAS 突变占人类肿瘤中所有 RAS ...

Preclinical analysis and clinical validation to identify biomarkers for trifluridine/tipiracil (FTD/TPI) efficacy with or without bevacizumab in patients with metastatic colorectal cancer. This is an ...

Cardiff Oncology's Onvansertib shows promise in treating RAS-mutated cancers, especially mCRC. See why I rate CRDF stock as a ...

Insilico Medicine’s Robotics Lab in Suzhou, China. Researchers from the artificial intelligence (AI)-based drug developer and the University of Toronto showed in a newly published study how AI ...

Dr. Marwan G. Fakih explains that KRAS mutations, found in 45% of patients with colorectal cancer, include the rare KRAS G12C mutation, leading to Lumakras approval. According to the National Cancer ...

Jazz Pharmaceuticals has agreed another pipeline-building deal, this time paying $10 million upfront for rights to a KRAS inhibitor programme from UK biotech Redx Pharma, continuing a move into ...

This important study demonstrates the potential of synthetic gene circuits to detect and target aberrant RAS activity in cancer cell lines. The circuit design is novel and the evidence supporting the ...