New research published in Nature Communications reveals how cancer cells are altered by their surroundings, enabling them to ...

Scientists have unlocked the mysteries of the 'extracellular matrix' which holds tumours together and the discovery could ...

They saw that extracellular matrix fibres at the outer edges of tumours pointed away from the malignancy, providing a “track” ...

Clinical-stage drug development company Syntara (ASX:SNT) has announced new findings from a subgroup analysis of 14 patients ...

lysyl oxidase and vascular endothelial growth factor). Both acute and chronic hypoxia exist in human tumours and these may have different biological consequences as a function of changes in ...

Scientists are looking at a range of different drug classes, such as lysyl oxidase (LOX) inhibitors and NADPH-oxidase inhibitors – but an obvious choice is a class of drugs known as autotaxin ...

We have also studied the role of cross-linking enzymes such as transglutaminase and Lysyl Oxidase like Enzyme 2 in the pathobiology of age-related vascular stiffness. We have shown that increases in ...

They also found that ciprofloxacin decreased lysyl oxidase expression and activity, increased matrix metalloproteinase levels and activity, and increased elastic fiber fragmentation and cell injury.