The following is a summary of “Anakinra improves retention rate of targeted treatments in Erdheim-Chester disease,” published ...

Researchers have discovered how a particular protein affects the growth and spread of colon cancer in humans. The study not ...

Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated kinase cascade and the VEGF pathway are commonly observed in breast cancer cells leading to malignant cell ...

In a report released today, Roger Song from Jefferies maintained a Buy rating on Kura Oncology (KURA – Research Report), with a price target of ...

“With the addition of VS-7375, a potential best-in-class oral KRAS G12D (ON/OFF) inhibitor, we are well-positioned to further establish our leadership in targeting RAS/MAPK pathway-driven cancers, ...

Pfizer Inc. (NYSE: PFE) today announced positive results from the Phase 3 BREAKWATER trial evaluating BRAFTOVI® (encorafenib) in combination with cetuximab (marketed as ERBITUX® ) and mFOLFOX6 ...

inspired by the promise of targeting cancer-associated molecular pathways upstream of other targets like RAS/ERK MAPK, which drive cellular proliferation and survival. According to BridgeBio and ...

Pfizer’s BREAKWATER trial of Braftovi combo regimen demonstrates improved response in patients with BRAF V600E-mutant metastatic colorectal cancer: New York Tuesday, January 28, ...

This indicates that ERK activation is crucial for T cell activation, and this was reported to be mediated by the AP-1 family of transcription factors. “The JNK signalling pathway is a cell stress ...

Precise detail is given to fulfill God's will. The exceedingly great importance of the Ten Commandments written by God's own finger! The high priest foreshadows Christ, our great High Priest (Heb.

This study presents fundamental insights into overcoming resistance in hormone receptor-positive breast cancer by demonstrating that sustained CDK4/6 inhibitor treatment, either alone or in ...