Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

Cdks are functional homologs across eukaryotes and are the engines that drive cell cycle events and the clocks that time them. Their function is counteracted by stoichiometric inhibitors; specifically ...

Anaplastic lymphoma kinase (ALK ... ALK signalling induces cell transformation in vitro and in vivo by controlling key cellular processes such as cell-cycle progression, survival, cell migration ...

One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in many aspects of immune mediated inflammatory responses ...

PEITC, a natural compound derived from cruciferous vegetables, induces oxidative stress, while dasatinib, a tyrosine kinase inhibitor, disrupts cancer cell signaling. The combination of these agents ...

Get Instant Summarized Text (Gist) A new computational tool, scEGOT, enhances the analysis of cell differentiation by mapping single-cell dynamics with high precision and efficiency. It identifies ...

Correlates of Cetuximab Efficacy in Recurrent and Metastatic Head and Neck Squamous Cell Carcinoma Previously Treated With Immunotherapy MAP2K1 ... However, the clinical efficacy of mitogen-activated ...

Get Instant Summarized Text (Gist) A detailed map of endothelial cells in the human pancreas has been created, revealing potential pathways for diabetes treatment. This map focuses on islet ...

NOTE. P < .00357 represents statistical significance after the Bonferroni correction. Abbreviations: MAPK, mitogen-activated protein kinase; NA, unable to be calculated; NR, not reached; OS, overall ...

T cells, which are the frontline warriors in the battle against infections, have been a major focus of research. Regulatory T cells (Tregs) are specialized immune cells that have a challenging ...

scEGOT, which is short for single-cell trajectory inference framework based on entropic Gaussian mixture optimal transport, is a comprehensive framework that allows researchers to map dynamic cell ...