In the present experiments the effects on insulin secretion of theophylline, a methyl xanthine derivative which inhibits cyclic nucleotide phosphodiesterase 6 and increases the intracellular ...

JMU scientists studied insulin-producing cells in fruit flies, finding that secretion is influenced by gut hormones, ...

"In humans, this phenomenon is known as the incretin effect," explains Dr. Ache. It suggests that insulin secretion is not simply controlled by the rise in blood sugar levels, but by more complex ...

Nutritional state-dependent modulation of insulin-producing cells in Drosophila. Rituja S. Bisen, Fathima Mukthar Iqbal, Federico Cascino-Milani, Till Bockemühl, Jan M. Ache. eLife, 29 January 2025, ...

Reduced insulin secretion leads to elevated blood glucose levels and an increased risk of serious complications, such as cardiovascular disease and nerve damage. The exact mechanisms behind ...

Ache. It suggests that insulin secretion is not simply controlled by the rise in blood sugar levels, but by more complex mechanisms involving gut hormones. The JMU team also found that IPC ...

Impairment of insulin secretion and defects in insulin action ... production of polyol compounds from glucose are among the mechanisms thought to produce tissue damage from chronic hyperglycemia.

Bromocriptine has not been shown to augment insulin secretion or enhance insulin sensitivity ... composite cardiovascular end point by 40%. The mechanism of the drug's beneficial effect on ...