In the present experiments the effects on insulin secretion of theophylline, a methyl xanthine derivative which inhibits cyclic nucleotide phosphodiesterase 6 and increases the intracellular ...

JMU scientists studied insulin-producing cells in fruit flies, finding that secretion is influenced by gut hormones, ...

Insulin-like growth factor (IGF) 1 is a member of a family that is involved in growth, development, cell differentiation, and metabolism. IGF1, IGF2 and insulin act primarily through tyrosine ...

In this context, proinsulin and the enzymes involved in the post-translational processing to mature insulin are retained within the beta cell secretory granule, while other proteins designated for ...

"In humans, this phenomenon is known as the incretin effect," explains Dr. Ache. It suggests that insulin secretion is not simply controlled by the rise in blood sugar levels, but by more complex ...

Ache. It suggests that insulin secretion is not simply controlled by the rise in blood sugar levels, but by more complex mechanisms involving gut hormones. The JMU team also found that IPC ...

School of Life Sciences, Fudan University, Shanghai, China International Human Phenome Institute (Shanghai), Shanghai, China Department of Endocrinology and Metabolism, Huashan Hospital, Fudan ...

This phenomenon, known as the incretin effect in humans, suggests that insulin secretion is not solely triggered by elevated blood sugar levels. Instead, it involves a more complex interplay of ...

The authors identified new target elements for prostaglandin E2 (PGE2) through which insulin release can be regulated in pancreatic beta cells under physiological conditions. In vitro extracellular ...