Transcriptomic analysis of monosomy X (45,X) tissues during early human fetal development provides insight into sex chromosome gene dosage and potential mechanisms and management in Turner syndrome.

(A condition in which there is an absence of a sex chromosome in the egg or the sperm may result in conditions such as Turner syndrome, a "monosomy" which has the arrangement 45, XO.) Nondisjunction ...

为探究特纳综合征（TS）发病机制及 X 单体（45,X）妊娠流产原因，伦敦大学学院研究人员开展 45,X 胎儿及胎盘转录组研究。发现相关基因表达变化，明确 CSF2RA 在胎盘的作用。该研究为 TS 研究提供关键依据，值得科研人员一读。