“I feel like they’re mostly happy,” said Erin Binder. Her sons, Jace and Grady, live with Pantothenate Kinase-Associated Nuerodegeneration, or PKAN for short. The now 13-year-olds have been ...

Physical activity is not only important for fitness, but also for health. This is confirmed by a new study conducted under the direction of Prof. Dr. Maximilian Kleinert at the German Institute of ...

Your body produces the enzyme creatine kinase (CK) or creatine phosphokinase to keep your muscles functioning properly. Healthcare providers use the CK test to check levels of this protein in your ...

PINK1 phosphorylates MIRO and activates Parkin mediated ubiquitination and degradation of MIRO. MFN1, mitofusin 1; MFN2, mitofusin 2; OPA1, optic atrophy 1; LRRK2, leucine-rich repeat kinase 2; VPS35, ...

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase first identified in a chromosomal translocation associated with some anaplastic large cell lymphomas (ALCL), a subset of T-cell non ...

Two sphingosine kinase isoforms, sphingosine kinase 1 (SPHK1) and sphingosine kinase 2 (SPHK2), synthesize S1P by phosphorylating sphingosine. While SPHK1 is a cytoplasmic kinase, SPHK2 is localized ...

Correspondence to Dr Verity McClelland, Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's ...

Doses found in commercial supplements range from 10 to 1,000 mg. Calcium pantothenate and pantethine are other common forms of the vitamin. The recommended daily intake of pantothenic acid for anyone ...

One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in many aspects of immune mediated inflammatory responses ...