Caption Analysis showed that IRBIT knockout (KO) mice (right) had significantly more phosphorylated tyrosine hydroxylase than wild type control mice (left). This led to abnormally high levels of ...

For example, tyrosine phosphorylated proteins have been shown to bind to Src homology 2 (SH2) and phosphotyrosine binding (PTB) domains 2, whereas serine/threonine phosphorylated proteins have ...

To enrich for proteins that are phosphorylated on tyrosine—the minority of all phosphorylated proteins in a cell—researchers in Arthur Salomon's group at Brown University added an ...

Alumis has revealed encouraging results from a Phase I clinical trial of a selective tyrosine kinase 2 (TYK2 ... This was measured by the levels of phosphorylated STAT proteins.

The most often studied kinases are protein kinases, which are generally subdivided into tyrosine, and serine/threonine-directed ... in which exposures of phosphorylated peptide substrates are taken as ...