Tyrosine phosphorylation of the EGFR leads to the recruitment of other signaling proteins including phospholipase Cγ and the non-receptor tyrosine kinase c-Src. EGFR activation also leads to ...

This content introduces the physiological and pathological importance of protein kinases, kinase inhibitors approved for ...

The intestinal epithelium is a highly dynamic barrier that regulates digestion, absorption, immune responses, and communication between the gut microbiota and the nervous system.

Melbourne-based scientists have, for the first time, discovered how to "switch off" a molecule which is one of the top ...

Medically reviewed by Richard N. Fogoros, MD Your body produces the enzyme creatine kinase (CK) or creatine phosphokinase to ...

NOTE. P < .00357 represents statistical significance after the Bonferroni correction. Abbreviations: MAPK, mitogen-activated protein kinase; NA, unable to be calculated; NR, not reached; OS, overall ...

Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.

Physical activity is not only important for fitness, but also for health. This is confirmed by a new study conducted under ...

Cystic fibrosis is a life-threatening disease predominantly with respiratory symptoms. Most of the subjects with the disease harbor the F508del variant in the CFTR gene that causes the protein to ...