In cancers, all translocations involving ALK produce fusion proteins with constitutive tyrosine kinase activity that in most cases derives from spontaneous dimerization induced by the different ...

T cell protein tyrosine phosphatase (TCPTP), a vital regulator in glucose metabolism ... TCPTP regulates diverse signaling pathways by dephosphorylating distinct substrates [e.g., Janus activated ...

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high ...

which dampens T-cell immune function through the cAMP/protein kinase A (PKA) signaling pathway. Indeed, the cAMP/type I PKA/Csk/Lck [lymphocyte-specific protein tyrosine kinase (PTK)] signaling module ...

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high ...

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high morbidity and mortality worldwide. In affected people, insulin is unable to ...

E1s and E2s first work generically across the cell to activate and prepare ubiquitin for attachment. E3 ligases then ensure that the tag is added to the right protein; as such, hundreds of specific ...

Mutation of one such tyrosine, Y169, located in proximity to the active site ... of an intriguing phospho-transfer reaction that helps accomplish the desired specificity. Protein purification, ...

The introduction of anti-VEGF agents has revolutionized the field of medical retina care by reducing rates of vision loss and ...

Verastem Oncology (Nasdaq: VSTM), a biopharmaceutical company committed to advancing new medicines for patients with RAS/MAPK ...

Blockade of caspase-3, but not inhibition of tyrosine kinase dependent pathways, prevented the alterations in TJ protein expression and permeability induced by the Fas/FasL system in human alveolar ...

Adrenomedullin (ADM) inhibits endothelial insulin signaling, contributing to obesity-associated insulin resistance, according ...