The cyclic AMP/protein kinase A (cAMP/PKA) pathway is one of the most common and versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target PKA to specific substrates ...

However, while the formation a ternary complex is crucial, it may not always guarantee successful protein degradation. The dynamics of the PROTAC-induced degradation complex play a key role in ...

Caspase recruitment domain and membrane-associated guanylate kinase-like protein 3 (CARMA3) is a scaffold protein widely expressed in ... Upon activation, CARMA3 forms a complex with BCL10 and MALT1, ...

There are other examples of double-sided UIMs, including human co-chaperone heat-shock protein DnaJ homologue (HSJ1), MAP kinase kinase kinase 1 (MAP3K1) and the endocytic regulators epidermal ...

One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in many aspects of immune mediated inflammatory responses ...

Subsequently, additional Ub polypeptides can be covalently attached to the first Ub to create a poly-Ub chain that eventually directs the client protein for proteasomal degradation.5,6 Ub itself is a ...

Your body produces the enzyme creatine kinase (CK) or creatine phosphokinase to keep your muscles functioning properly. Healthcare providers use the CK test to check levels of this protein in your ...

a protein involved in PER degradation, and Lys1117 and Lys1118 are key ubiquitination sites critical for maintaining PER stability. Aspirin is a potent lysine acetylation inducer, but its impact ...

Getting enough protein daily is essential for your overall health. Healthy protein sources include eggs, nuts, lean meats, fish, dairy, and certain grains. Proteins are a large category of ...

People with diabetes should eat as much protein as people who don't have diabetes. In a healthy diet, roughly 10% to 35% of your daily calories should come from protein. Protein itself does not have ...

Before choosing the best protein powders, our testers and dietitians evaluated more than 100 different animal-based and whey protein powders, considering factors like ingredients, taste ...