Researchers from Morphic Therapeutic Inc. and affiliated organizations published data from a study that aimed to assess the potential of using arginylglycylaspartic acid (RGD) integrins for the ...

Department of Nuclear Medicine, School of Medicine & Health, Klinikum rechts der Isar, TUM University Hospital, Technical University of Munich, Ismaninger Strasse 22, Munich 81675, Germany Central ...

State Key Laboratory of Biochemical Engineering, Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P. R.

Figure 3: K14.MYC2 primary keratinocytes exhibit a defect in migration. Figure 4: K14.MYC2 epidermis exhibits reduced staining for β1 integrin.

Integrins are very attractive therapeutic targets in oncology. The anti-tumor mechanisms of integrin-targeting drugs have been validated both in vitroand in vivo. Integrin-targeting drugs are ...

The decision affects THR-687, a pan RGD integrin antagonist for the treatment of diabetic macular oedema (DME), and leaves Oxurion with a single clinical-stage candidate – plasma kallikrein ...

The RGD motif is highlighted in yellow, where it is preserved across all major variants ... Since integrins are critical receptors for multiple cellular functions, potential side effects of ...

The Arginine - Glycine - Aspartic acid (Arg-Gly-Asp, RGD) peptide family is considered as a specific recognition site for the integrin receptors. Integrin receptors are key regulators of cell-cell and ...

During amphibian gastrulation, presumptive endoderm is internalised as part of vegetal rotation, a large-scale movement that encompasses the whole vegetal half of the embryo. It has been considered a ...

Both wild-type IGFBP-2 and HBD-mutant IGFBP-2 contain the RGD sequence that allows binding with α5β1 integrin receptors. It has been shown that α5β1 integrin receptor activation leads to FAK ...

Disruption of integrin α8 signalling inhibits fibronectin1‐mediated metalloproteinase activation and augments the rate of prion replication. Lineage of susceptible and resistant cell clones isolated ...