While performing a high-throughput screen (HTS) that identified the hits that led to the discovery of TNG908 and TNG462, we embarked on a structure-based design effort to switch the mechanism of ...

Vaccine Analytical Research & Development, Merck & Co., Inc., 770 Sumneytown Pike, P.O. Box 4, West Point, Pennsylvania 19486, United States ...

A catalytic mechanism is the sequence of elementary reactions by which a catalytic reaction proceeds. The behaviour of nanoconfined water can be very different from that of the bulk and is ...