koto.kpu-m.ac.jp Background/Aims To investigate the time-dependent change of corneal endothelial cell (CEC) morphology and density (CECD) in patients with glaucoma post instillation of rho-associated ...

The cyclic AMP/protein kinase A (cAMP/PKA) pathway is one of the most common and versatile signal ... and the anchoring protein phosphoprotein associated with glycosphingolipid-enriched microdomains ...

Belumosudil – a Rho-associated protein kinase-2 (ROCK2) inhibitor that reduces immune mediators like IL-17 and IL-23 – would be a first-in-class therapy for GVHD if approved by the FDA ...

Your body produces the enzyme creatine kinase (CK) or creatine phosphokinase to keep your muscles functioning properly. Healthcare providers use the CK test to check levels of this protein in your ...

One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in many aspects of immune mediated inflammatory responses ...

1.4 Associated with connective tissue disease, HIV infection, portal hypertension, congenital heart disease, schistosomiasis ALK-1 indicates activin receptor-like kinase 1; BMPR2, bone morphogenetic ...

The abundance of misfolded and aggregated forms of microtubule-associated protein tau (also known as MAPT ... GSK-3β-directed PROTACs by altering the PTM profile of tau protein through the degradation ...

The Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1R) families are of paramount importance in coordinating the early immune response to pathogens. Signaling via most TLRs and IL-1Rs is ...

Objectives Casein kinase II (CK2) is a constitutively active serine/threonine protein kinase that plays a key role in cellular transformation and tumorigenesis. The purpose of the study was to ...

Non-coding RNAs (ncRNAs) are RNA molecules that do not encode proteins, but play important roles in gene expression regulation, cell differentiation, apoptosis, metabolism, and other physiological ...