Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.

Protein phosphorylation is a cornerstone of cellular communication, orchestrating rapid and precise responses to ...

CIRBP Family, Tumors, Molecular Mechanisms, RNA-Binding Proteins, Cellular Stress Share and Cite: Cai, Y. , Wang, T. and Zhan ...

This study presents solid evidence for distinct neurotransmitter release modalities between two subclasses of dopaminergic neurons in the olfactory bulb, highlighting an important finding that ...

Besides this, there are emerging findings that myeloid cells could be involved in tumor angiogenesis. In this article, we address the role of tyrosine kinase inhibitors in tumor immunology by ...

The cyclic AMP/protein kinase A ... to regulatory T cell (Treg) suppression and inflammatory mediators, such as prostaglandins (PGs), adrenergic stimuli, adenosine, and a number of other ligands. A ...

Both of ACE2 and transmembrane serine protease 2 (TMPRSS2) are key proteins of severe acute respiratory syndrome coronavirus (SARS ... After removing unwanted sources of variation, such as cell cycle ...

Before choosing the best protein powders, our testers and dietitians evaluated more than 100 different animal-based and whey protein powders, considering factors like ingredients, taste ...

A "pocket" on the protein ... cell division when the pocket loses its shape and can no longer dock onto the substrate." The reason for this lies in the cyclins' cooperation with a kinase.

A research team revealed that insulin-like growth factor-binding protein 6 (IGFBP6 ... IGFBP6 is known to play a crucial role in regulating cell cycle, proliferation, migration.

1Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California.

Intracellular kinases play a ubiquitous role in signaling pathways within cells. Receptor tyrosine kinases ... tyrosine kinases and serine/threonine protein kinases function throughout cascades ...