Signal transducer and activator of transcription 6 (STAT6) is a member of the STAT family involved in the regulation of immune response and inflammation. The development of SH2 domain inhibitors ...

In contrast to PTB domains, the structurally distinct SH2 domains are highly specialized for the recognition of pTyr. Specificities of binding for individual SH2 domains can in many cases be ...

Recludix Pharma, a leader in the discovery of inhibitors of challenging targets for inflammatory disease, today announced ...

In addition, SYK mediates differentiation through the adaptor protein SH2-domain-containing leukocyte protein of 65 kDa (SLP65), which induces the activation of IgL gene recombination. Pre-BCR sig ...

Protein phosphorylation is a cornerstone of cellular communication, orchestrating rapid and precise responses to ...

This signal functions as ‘on and off’ switches that links the receptors to their intracellular signalling machinery working as temporal scaffolds for Src homology 2 (SH2) domains of downstream ...

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(Figure 2). Janus Kinase 2 (JAK2) is a tyrosine kinase belonging to the Janus family that has only one catalytic structural domain and no Src homology 2 (SH2) structural domain. Therefore, JAK2 can ...

Emergency services were called to the scene of a single-vehicle crash on SH2 at Tutira about 3.50pm. Photo / File A serious crash closed a section of State Highway 2 in Hawke’s Bay this afternoon.

Police received a report of a two vehicle crash on SH2, Athenree Gorge near Arden Road at around 4pm. File / Photo There has been a crash on SH2, Athenree Gorge, near Arden Road. A police ...

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One of the Wellington region's busiest roads, State Highway Two through the Hutt Valley will be severely disrupted when Wellington Water digs up an aging sewerage pipe that runs under it. Nick James ...