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Researchers believe the innovative idea holds immense promise for tackling a wide range of diseases including cancer through ...

As noted above, stellate cell activation is the central event in ... metalloproteinases has been identified that are calcium-dependent enzymes which specifically degrade collagens and ...

The three-signal model provides an empirical framework for innate instruction of adaptive immunity, but mainly discusses STAT-dependent cytokines in T cell activation and differentiation, while the ...

BCMA Stimulates plasma cell ... B cells have a role in the regulation of CNS inflammation Autoantibodies against glycolipids and glycoproteins can induce demyelination within the PNS T-cell ...

Here the authors show, by focusing on an HLA-A3-bound neoantigen and its WT counterpart, the allosteric formation of a peptide-dependent ... and activation of HLA-B-restricted T cells, thereby ...

Dark zone lymphoma includes aggressive B-cell lymphomas with shared molecular features. While some respond to escalated ...

Our results might suggest a potential role of activated Tph and Tfh in activation and differentiation of B-cells, as suggested by the association between these cells and some B cells markers ...

Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical ...

In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.

B-cells produce antibodies to attack bacteria and viruses that enter the body. T cells directly attack foreign invaders and cancer cells and produce chemicals that activate other immune cells.